Jingai Makyou

The main character is a Japanese college student, who lost his parents in an accident and since then has been cared for by his landlady. He has a strange set of eyes, with one green eye and one red eye. His little sister Megumi, goes to boarding school in England, but still comes back to visit him from time to time.

His best friend Ryou has always been supportive of the main character and has stuck by him through thick and thin.